Has many complex proteins and so have a robust system for heat-shock protein assisted folding9/26/2023 In accordance, transgenic activation of the heat shock response prolonged survival time after infection and enabled long-term control of virus replication to undetectable levels. Hsf-deficient adult flies were hypersensitive to virus infection, indicating a role of the heat shock response in antiviral defence. The heat shock transcription factor ( Hsf), as well as active viral replication, were necessary for the induction of the response. Dynamic induction patterns of heat shock pathway components were characterized in vitro and in vivo following infection with different classes of viruses. Transcriptome analyses of Drosophila S2 cells and adult flies revealed strong induction of the heat shock response upon RNA virus infection. This study describes the heat shock response, a cellular mechanism that prevents proteotoxicity, as a component of the antiviral immune response in Drosophila. Drosophila is an emerging model to study viral pathogenesis, yet antiviral defence responses remain poorly understood. Innate immunity is the first line of defence against pathogens and is essential for survival of the infected host. The heat shock response restricts virus infection in Drosophila. Keyword(s) - heat shock factor and heat shock proteinsĬellular location - cytoplasmic and nuclear
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